Fig 5.

Thyroid-specific down-regulation of NIS protein. Sagittal sections of wild-type (A and E), tshr^hyt/tshr^hyt (B and F), pit1^dw/pit1^dw (C and G), and TSHR-KO (D and H) E17.5 thyroids and salivary glands were stained with anti-NIS antibody. Salivary glands shown in E–H belong to the embryos shown in A–D, respectively. NIS expression is very scarce in the thyroid of mutant embryos. In contrast, a clear signal is present in the salivary glands. These data are representative of at least two independent experiments. As controls, wild-type C57BL/6 embryos were used.