Fig 2.

(a) Analysis of miR15/16 cluster expression in human tissues by Northern blotting reveals that the two genes are ubiquitously expressed, with the highest levels in normal CD5+ cells. (b) The majority of CLL samples express lower levels of miR16 and miR15 as normal CD5+ cells. The LOH status for the presented samples is shown as: +/+, heterozygosity; +/−, LOH; −/−, homozygous deletion; NI, not informative; ND, not done. As normalization controls, we used staining with ethidium bromide of Northern gels.