Table 1.

Tumor incidence in Pold1^D400A mice

Tumor	Incidence
	Pold1+/+	Pold1+/D400A	Pold1D400A/D400A
Carcinoma
Skin squamous	0	0	31
Lung adeno	0	0	7
Other adeno	1	1	2
Total	1 (2%)	1 (1%)	40 (63%)
Lymphoma
Thymic	0	0	15
Diffuse abdominal	0	2	4
Total	0	2 (2%)	19 (39%)
Sarcoma
Histiocytic	0	0	3
Fibro	0	0	1
Hemangio	1	0	0
Rhabdomyo	0	0	1
Total	1 (1%)	0 (0%)	5 (10%)
Teratoma	0 (0%)	0 (0%)	2 (4%)
No. of mice with tumors/  total no. of mice	2/53 (4%)	3/97 (3%)	46/49 (94%)

Values represent the number (and percentage) of animals with the indicated tumor. Seven, six, and three Pold1^+/+, Pold1^+/D400A, and Pold1^D400A/D400A mice, respectively, had no visible tumors at autopsy. There were no significant differences in cancer incidence by gender.

^*Sixteen Pold1^D400A/D400A mice (33%) developed tumors in more than one tissue (12 with two tumors and four with three tumors); all of these had skin squamous cell carcinoma (SCC) as one of the tumor types. A total of 66 different tumors were observed in 49 Pold1^D400A/D400A mice. Mice with multiple SCCs were scored as having a single tumor of this type.

^† Includes 27 mice with tail tumors, two with both tail and ear tumors, one with tail tumors and a hind paw tumor, and one with an isolated ear tumor.

^‡ Includes three myoepitheliomas (one from each genotype) derived from either breast or salivary glands and a Pold1^D400A/D400A adenocarcinoma of the uterus with metastases to the lung.

^§ All nine mice with adenocarcinomas also had skin SCCs. Thus, 31 of the 49 Pold1^D400A/D400A mice (63%) developed carcinomas in one or more tissues.