Table 1.
Tumor
|
Incidence | ||
---|---|---|---|
Pold1+/+ | Pold1+/D400A | Pold1D400A/D400A | |
Carcinoma | |||
Skin squamous | 0 | 0 | 31 |
Lung adeno | 0 | 0 | 7 |
Other adeno | 1 | 1 | 2 |
Total | 1 (2%) | 1 (1%) | 40 (63%) |
Lymphoma | |||
Thymic | 0 | 0 | 15 |
Diffuse abdominal | 0 | 2 | 4 |
Total | 0 | 2 (2%) | 19 (39%) |
Sarcoma | |||
Histiocytic | 0 | 0 | 3 |
Fibro | 0 | 0 | 1 |
Hemangio | 1 | 0 | 0 |
Rhabdomyo | 0 | 0 | 1 |
Total | 1 (1%) | 0 (0%) | 5 (10%) |
Teratoma | 0 (0%) | 0 (0%) | 2 (4%) |
No. of mice with tumors/ total no. of mice | 2/53 (4%) | 3/97 (3%) | 46/49 (94%) |
Values represent the number (and percentage) of animals with the indicated tumor. Seven, six, and three Pold1+/+, Pold1+/D400A, and Pold1D400A/D400A mice, respectively, had no visible tumors at autopsy. There were no significant differences in cancer incidence by gender.
Sixteen Pold1D400A/D400A mice (33%) developed tumors in more than one tissue (12 with two tumors and four with three tumors); all of these had skin squamous cell carcinoma (SCC) as one of the tumor types. A total of 66 different tumors were observed in 49 Pold1D400A/D400A mice. Mice with multiple SCCs were scored as having a single tumor of this type.
Includes 27 mice with tail tumors, two with both tail and ear tumors, one with tail tumors and a hind paw tumor, and one with an isolated ear tumor.
Includes three myoepitheliomas (one from each genotype) derived from either breast or salivary glands and a Pold1D400A/D400A adenocarcinoma of the uterus with metastases to the lung.
All nine mice with adenocarcinomas also had skin SCCs. Thus, 31 of the 49 Pold1D400A/D400A mice (63%) developed carcinomas in one or more tissues.