Table 1.
Clinical data of subjects used in our study
| Subjects
|
Sample intervals, years
|
Sample number
|
Age, years
|
Age at infection, years
|
Risk factors
|
Gender
|
Race
|
HBc Ab
|
Degree of chronic hepatitis, HAI | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mild | Moderate | Bridging | Cirrhosis | |||||||||
| CF | 15.6 | 4 | 71 | 48 | BTF (1977) | M | B | Neg | X | |||
| FM | 20.6 | 5 | 55 | 32 | BTF (1978) | M | W | Neg | X | |||
| JL | 21.6 | 4 | 52 | 24 | BTF (1973) | F | B | Neg | X | |||
| HW | 17.7 | 7 | 84 | 60 | BTF (1977) | M | W | Neg | X | |||
| PR | 15.5 | 4 | 62 | 39 | BTF (1978) | M | W | Neg | X | |||
| PEN | 17.8 | 4 | 53 | 29 | BTF (1977) | M | W | Neg | X | |||
| KM | 19 | 2 | 76 | 46 | BTF (1971) | M | W | Neg | X | |||
| C107 | 8 | 2 | 41 | <21 | IDU (1972) | F | W | Neg | X | |||
| C115 | 8.1 | 2 | 44 | <24 | Unknown | M | W | Neg | X | |||
| C159 | 7 | 2 | 49 | 29–33 | OPE (1989) | F | B | Neg | X | |||
The first seven subjects were enrolled in prospective studies of transfusion-associated hepatitis conducted at the National Institutes of Health starting in 1972 (15) and the final three subjects were from anti-HCV positive blood donors whose exposure history suggested infection of >20 years' duration (16).
*
BTF, blood transfusion; IDU, injection drug user; OPE, surgical operation. The putative infection time appears in parentheses.
†
B, African American; W, Caucasian; HBcAb, antibody to HBV core antigen; Neg, negative.