Fig. 1.

Progesterone affects glucose homeostasis in vivo. (A) Regression analysis of plasma glucose levels plotted against plasma progesterone levels in 51 female B57CL/6J nonfasted mice. (B) Time course of fasting plasma glucose levels in female db/db mice chronically treated with either vehicle or progesterone. (C) Fasting blood glucose levels in +/? and db/db mice treated daily for 2 weeks with either vehicle or RU486 (30 mg/kg). *, A significant difference compared to the vehicle-treated counterparts (P < 0.05).