Fig. 2.

Improved glucose tolerance in female PR−/− mice. (A) Plasma glucose concentrations in male and female PR+/+ and −/− mice after a 6-h fast (n = 11–12). (B) Plasma insulin levels in male and female PR+/+ and −/− mice after a 6-h fast (n = 11–12). (C) Glucose tolerance test in overnight fasted female PR+/+ and −/− mice. Mice were injected with glucose (2 g/kg), and glycemia was monitored at indicated time points. (D) Plasma insulin levels measured during the glucose tolerance test in C. *, A significant difference compared to the WT counterparts (P < 0.05). Black symbols represent PR−/− mice and white symbols represent the PR+/+ genotype (n = 10–11 mice).