Fig. 3.

Lack of PR results in an enhanced insulin secretion. Isolated islets from PR+/+ and −/− mice were exposed to increasing concentrations of glucose (A), with 20 mM arginine (B), or in the presence of 16.6 mM glucose and 1 μM diazoxide, 30 mM KCl, or 20 mM arginine. Insulin concentration in the medium was measured 30 min later. Data were corrected on a per islet (A and B) or per milligram of protein (C) basis. Experiments were done in triplicate. One representative experiment of two is shown. *, See Fig. 2 for statistical significance.