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. 2002 Nov 15;99(24):15644–15648. doi: 10.1073/pnas.202612199

Fig. 5.

Fig. 5.

Lack of PR in female mice promotes β-cell proliferation. (A) BrdUrd (blue) and insulin (red) coimmunofluorescent staining of pancreatic sections from female, 30-d-old PR+/+ and −/− mice injected with 50 mg/kg BrdUrd. The pancreas was harvested 3 h after the injection. (B) Annexin (red) and insulin (green) coimmunofluorescent staining of pancreatic sections used in A. The counts of BrdUrd- and annexin-positive β-cells in pancreatic sections described in A and B were done on five sections cut with a 20-μm thickness interval in five different animals per genotype. *, See Fig. 2 for statistical significance. (C) Protein levels of p53 and β-actin in pancreatic islets isolated from female PR+/+ and −/− mice. Homogenates were processed by Western blotting.