Fig 1.

Courses of acute HCV infection in chimpanzees after experimental inoculation with HCV. Quantitative HCV RNA levels were expressed as log GEs per milliliter of serum. HCV RNA was also monitored by in-house RT-nested PCR, and results are indicated as + or −. ALT activity was expressed as units per liter. HCV antibody responses reflect the results of an HCV EIA-2 assay as described in Materials and Methods. Liver biopsies were examined for necroinflammatory changes and scored as described (22).