Table.

Fatal toxicity index (deaths per million prescriptions) for antidepressants ranked within British National Formulary classes

Drug	No of prescriptions (thousands)	Total deaths	Deaths/million prescriptions (95% CI)
Tricyclic antidepressants and related drugs:	74 598	2598	34.8 (33.5 to 36.2)
Desipramine	45	9	200.9 (92.0 to 381.6)
Amoxapine	107	10	93.5 (44.8 to 171.8)
Dothiepin	26 210	1398	53.3 (50.5 to 56.1)
Amitriptyline	23 844	906	38.0 (35.5 to 40.5)
Imipramine	3 354	110	32.8 (27.0 to 39.5)
Doxepin	1 587	40	25.2 (18.0 to 34.3)
Trimipramine	2 370	39	16.5 (11.7 to 22.5)
Clomipramine	4 315	54	12.5 (9.4 to 16.3)
Nortriptyline	1 269	7	5.5 (2.2 to 11.4)
Maprotiline	201	1	5.0 (0.1 to 27.7)
Trazodone	2 753	11	4.0 (2.0 to 7.1)
Mianserin	922	3	3.3 (0.7 to 9.5)
Mirtazapine	324	1	3.1 (0.1 to 17.2)
Lofepramine	7 189	9	1.3 (0.6 to 2.4)
Butriptyline	1	0	0 (0 to 3372)
Iprindole	3	0	0 (0 to 1218)
Viloxazine	10	0	0 (0 to 357.2)
Protriptyline	94	0	0 (0 to 39.2)
Serotoninergic drugs:	47 329	77	1.6 (1.3 to 2.0)
Venlafaxine	2 570	34	13.2 (9.2 to 18.5)
Fluvoxamine	660	2	3.0 (0.3 to 10.9)
Citalopram	2 603	5	1.9 (0.6 to 4.5)
Sertraline	5 964	7	1.2 (0.5 to 2.4)
Fluoxetine	19 926	18	0.9 (0.5 to 1.4)
Paroxetine	15 031	11	0.7 (0.4 to 1.3)
Nefazodone	576	0	0 (0 to 6.4)
Monoamine oxidase inhibitors:	1 203	24	20.0 (12.8 to 29.7)
Tranylcypromine	367	16	43.6 (25.0 to 70.9)
Phenelzine	404	6	14.9 (5.5 to 32.4)
Moclobemide	365	2	5.5 (0.6 to 19.8)
Iproniazid	0.2	0	0 (0 to 18 444)
Isocarboxazid	68	0	0 (0 to 54.6)
Other antidepressants:	2 523	1	0.4 (0 to 2.2)
Flupentixol	2 320	1	0.4 (0 to 2.4)
Tryptophan	28	0	0 (0 to 133.3)
Reboxetine	175	0	0 (0 to 21.1)
Lithium	5 106	37	7.2 (5.1 to 10.0)

Numbers may not add up to the total because of rounding.