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Habituation learning in a novel open field in PDAPP mice is normalized after treatment with m266. (A) PDAPP transgenic mice exhibited increased locomotor activity, which was reduced following treatment with the anti-Aβ antibody m266 (500 μg i.p.) but not following treatment with the anti-Aβ antibody 3D6 (500 μg i.p.). (B) Accumulated locomotor activity per 60-minute session. ***P < 0.001. n = 20 mice per group, 4–6 months of age.
