Figure 5.

When infused 30 days after surgery, soluble rCD154 induces rejection but platelets do not. (A) CD154KO animals that received rCD154 trimers 30 days after transplantation promptly rejected their allografts (n = 5; P = 0.008 versus untreated animals). Animals receiving platelet transfusions 30 days after transplantation did not reject (n = 5). (B) CD154-KO recipients that received human platelet transfusions on day 30 were euthanized 30 days after infusion and showed no evidence of rejection. Magnification, ×20. (C) Those receiving trimers had histologically typical rejection. Magnification, ×40.