Table 3.
Binding and catalytic properties of hPCAF and hPCAF(Y638A)
| AcCoAKm, μM | H3-20 Km, μM | kcat, s−1 | H3-(Me)CoA-20 IC50, nM | |
|---|---|---|---|---|
| WT hPCAF | 1.6 | 50 | 3.5 | 360 |
| Y638A hPCAF | 1.6 | 125 | 0.19 | 1,700 |
*
Measured with 180 μM H3-20 peptide.
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