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The deblocking after mispriming model for the role of TEIIs in nonribosomal peptide assembly. Apo to holo conversion of NRPSs is catalyzed by dedicated 4′PP transferases that accept CoA and acyl-CoA as substrates. If acyl-4′PP is the transferred cofactor, a TEII then hydrolyzes the acyl group and thereby regenerates a misprimed NRPS to the active free holo form.
