Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2002 Oct 7;99(22):14298–14302. doi: 10.1073/pnas.162491399

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2002, The National Academy of Sciences

PMC Copyright notice

Fig 1. — Cisplatin resistance of yeast mutants. Logarithmic-phase cells were exposed for 2 (A–C) or 3 (D) h to different concentrations of cisplatin and incubated on YPD plates at 30°C for 2 days to allow formation of colonies. Data are expressed as percentages of colonies formed compared with control cultures not exposed to cisplatin. (A) Cisplatin resistance of mutants defective in Mac1p target genes. Strains are wild-type (YSI1), mac1Δ (YSI9), ctr1Δ (YSI22), fre1Δ (YSI23), fre7Δ (YSI24), cta1Δ (YSI25), and ctt1Δ (YSI26). (B) Cisplatin resistance of mutants defective in intracellular copper trafficking and utilization. Strains are wild-type (YSI1), ctr1Δ (YSI22), atx1Δ (YSI28), ccc2Δ (YSI29), fet3Δ (YSI30), lys7Δ (YSI31), sod1Δ (YSI32), cox17Δ (YSI33), and sco1Δ (YSI34). (C) Cisplatin sensitivity of low-affinity copper transporter mutants, ctr2Δ (YSI35) and fet4Δ (YSI36). (D) Cisplatin sensitivity of high-affinity copper transporter mutants in the BR10 strain background (22). Strains were DTY1 (CTR1 CTR3), SKY52 (ctr1Δ CTR3), SKY44 (CTR1 ctr3Δ), and SKY46 (ctr1Δ ctr3Δ).