Fig 2.

Heightened susceptibility of TCRδ^−/− mice to DSS-induced colitis. Representative areas of normal mucosa, ulcerated mucosa after 3 days and 5 days of DSS treatment, and mucosal regeneration 3 days after termination of DSS treatment. Ulcerated areas are indicated by stars, and areas of surface re-epithelialization are indicated by an arrowhead. TCRδ^−/− mice had consistently more severe colonic damage compared with wild type. Evidence of regeneration, and in particular surface re-epithelialization, was scant 3 days after termination of DSS treatment. Similar results were obtained in three independent experiments. (Original magnification = ×200.)