Table 2.
Results of BLASTX searches: Catalogue of proteins expressed in hematopoietic and lymphocyte-like cells
| Clone | Similarity to | Species | Accession no. | Function |
|---|---|---|---|---|
| Genes controlling lymphocyte ontogeny | ||||
| Spi transcription factor | Petromyzon marinus | AAF78904 | Transcription factor | |
| Ikaros transcription factors | Petromyzon marinu | AAL67302/AAL62094 | Transcription factors | |
| 42A10 | Mast/stem cell growth factor receptor (tyrosine-protein kinase c-Kit) | Gallus gallus | Q08156 | Tyrosine protein kinase |
| 38A03 | Uncharacterized hematopoietic stem/progenitor cells protein MDS003 | Homo sapiens | NP_060938 | Unknown |
| Genes involved in lymphocyte signaling | ||||
| 26A03 | Human leukocyte common antigen CD45 | Homo sapien | NP_002829 | Protein-tyrosine phosphatase |
| 25F12 | B cell phosphoinositide 3-kinase adaptor (BCAP) | Mus musculus | NP_113553 | Links BCR-associated kinases with phosphatidylinositol 3-kinase |
| 51E10 | CD3 ɛ associated protein; antisense to ERCC-1 (CAST) | Homo sapiens | NP_036231 | T-cell activation |
| 11C05 | Activated protein kinase C receptor (RACK1) | Rattus norvegicus | A36986 | PRKC-mediated signaling |
| 12D11 | Thymosin β-10 | Rattus norvegicus | AAB37101 | Actin monomer sequestering protein |
| 79D04 | IgG Fc-binding protein | Homo sapiens | AAD39266 | Role in intestinal immune protection and inflammation |
| O8F12 | c-Kit-related kinase | Xenopus laevis | I51703 | Tyrosine protein kinase |
| 43B05 | Kit-like A | Lethenteron reissneri | BAA84745 | Tyrosine protein kinase |
| 14C11 | Tumor necrosis factor receptor superfamily member | Mus musculus | NP_035739 | Binding of tumor necrosis factor |
| 18A11 | Progesterone receptor-related protein p23 | Gallus gallus | B56211 | Chaperone, disrupting receptor-mediated transcriptional activation |
| 18B09 | Ran GTP-binding protein | Xenopus laevis | BAA89696 | GTP-binding protein |
| 30G05 | Protein tyrosine phosphatase | Mus musculus | CAA76755 | Protein tyrosine phosphatase |
| 34A04 | fms-related tyrosine kinase 3 | Homo sapiens | XP_012297 | Tyrosine kinase |
| 34E11 | Myc-binding protein | Xenopus laevis | I51586 | Myc binding, regulation of gene expression during differentiation |
| 36G05 | ATP-stimulated glucocorticoid-receptor translocation promoter | Rattus norvegicus | NP_077357 | Increases binding of activated glucocorticoid-receptor to nuclei |
| 48H11 | Lanthionine-synthetase component C-like protein-coupled receptor | Homo sapiens | NP_061167 | G protein-coupled receptor |
| 58B05 | Granalcin | Mus musculus | AAM66720 | Calcium binding |
| 11D11 | Calmodulin 2 | Homo sapiens | NP_001734 | Calcium binding |
| 06F07 | Calcium-dependent protein kinase SK5 | Glycine max | P28583 | Calcium-dependent signal transduction |
| Genes required for lymphocyte proliferation and migration | ||||
| 09D03 | CD98 | Homo sapiens | XP_043189 | Amino acid transporter |
| 87B05/78D10 | CD9/CD81 (target of antiproliferative antibody 1) | Bos taurus | P30932 | Tetraspanin receptors, participation in cell migration and adhesion |
| Rattus norvegicus | NP_037219 | |||
| Genes encoding proteasomal subunits and an ABC transporter | ||||
| 04A09 | ABCB9 | Homo sapiens | NP_062571 | ABC transporter |
| 55B12 | PSMB4 | Xenopus laevis | P28024 | Protein degradation |
| 93B06 | PSMB7 | Homo sapiens | AAH00509 | Protein degradation |
| 97D07 | 26S proteasome subunit pUb-R3 | Mus musculus | BAA97575 | Protein degradation |
| 66F06 | Proteasome subunit α type 2 (proteasome component C3) | Xenopus laevis | P24495 | Protein degradation |
| 23B08 | Proteasome subunit α type 6 | Mus musculus | NP_036098 | Protein degradation |
| 97G10 | Proteasome inhibitor PI31 subunit | Homo sapiens | NP_006805 | Protein degradation |
| Other immunologically relevant genes | ||||
| 06D11 | Chaperone protein dnaJ | Haemophilus ducreyi | P48208 | Chaperone |
| 34G10 | Heat-shock 90-kDa protein 1, β | Homo sapiens | XP_018115 | Chaperone |
| 29C10 | Heat-shock 90-kDa protein 1, α | Homo sapiens | NP_005339 | Chaperone |
| 34D12 | Heat-shock cognate 70 protein | Gallus gallus | CAA06233 | Chaperone |
| 73H07 | dnaK-type molecular chaperone hsp70 | Pleurodeles waltl | JC5642 | Chaperone |
| 84F09 | Heat-shock protein hsp70-related protein | Homo sapiens | XP_028530 | Chaperone |
| 97B07 | Heat-shock protein 86 | Homo sapiens | AAA36024 | Chaperone |
| 87A09 | Macrophage migration inhibitory factor | Gallus gallus | Q02960 | Regulation of macrophage function in inflammation |
| 25B03 | CXC chemokine receptor 4 | Acipenser ruthenus | CAB60252 | Directs migration of leukocytes in lymphoid organs |
| 15G09 | Cathepsin L | Myxine glutinosa | AAF19630 | Cysteine protease |
| 73A07 | Cystatin B thiol proteinase inhibitor | Homo sapiens | NP_000091 | Cysteine protease inhibitor |
| 92D12 | Egg-white cystatin; cystatin F; leukostatin | Gallus gallus | P81061 | Cysteine protease inhibitor |
| Homo sapiens | NP_003642 | |||
| 97A10 | Lysosomal trafficking regulator | Mus musculus | NP_034878 | Lysosomal traffic |
| 15E08 | Lymphocyte antigen 6 complex-related | Mus musculus | NP_034872 | GPI-linked cell-surface glycoprotein |
| 26C02 | Complement component 1, q subcomponent-binding protein | Mus musculus | NP_031599 | Multifunctional protein; regulation of complement system |
| 44BG01 | Hepsin | Homo sapiens | NP_002142 | Blood coagulation, fibrinolysis, complement activation |
| 70H12 | Glutathione-dependent hematopoietic prostaglandin D synthase | Gallus gallus | O73888 | Conversion of prostaglandin PGH2 to PGD2 |
| 49B02 | Zygin 2; fasciculation and elongation protein ζ 2; Pre-T/NK cell-associated protein (3C1) | Homo sapiens | NP_005093 | Axonal fasciculation in neural tissue |
| 13G06 | Mitogen-inducible gene 2 (mig-2) or talin | Homo sapiens | XP_051693 | Connects cytoskeletal structures to plasma membrane |
| 40A01 | Ribosome-associated membrane protein 4 (RAMP4) | Rattus norvegicus | CAB40910 | Controls glycosylation of MHC class II-associated invariant chain |
| 29A06 | Tumor necrosis factor-inducible protein TSG-6, (hyaluronate-binding protein PS4) | Oryctolagus cuniculus | P98065 | Hyaluronan-binding protein |
| 11B12 | Interferon-inducible protein 16 | Rattus norvegicus | NP_110460 | Unknown |
| 11E10 | Slit | Danio rerio | AAG36772 | Inhibits leukocyte chemotaxis |
| 92F05 | Dentritic cell protein DC6 | Homo sapiens | NP_064574 | Unknown |
| 46F05 | RW1 protein | Mus musculus | AAC15232 | Possible role in antiviral immune response |
| 58A07 | ADP-ribosylation-like factor-6 interacting protein (ARL6) | Homo sapiens | Q15041 | Role in hematopoietic maturation |
| 62D09 | Putative human HLA class II-associated protein | Homo sapiens | NP_006296 | Binding of cytoplasmic domain of the HLA DR-α chain |
| 17B05 | Thioredoxin | Oryctolagus cuniculus | P08628 | Redox reactions, augments expression of IL-2 receptor |
| 72D07 | Thioredoxin peroxidase 1 | Rattus norvegicus | NP_058865 | Immunoregulation of natural killer cell activity |
| 25D08 | Peroxidasin | Drosophila melanogaster | AAF47668 | Extracellular matrix-associated peroxidase in hemocytes |
| 75F03 | Peptidyl-prolyl cis-trans-isomerase (cyclophilin D) | Mus musculus | NP_032046 | Binds cyclosporin A |
| 83G05 | B cell translocation gene-2 (BTG2), antiproliferative | Mus musculus | NP_031596 | Cell-cycle progression |
| 84A11 | Tumor protein, translationally controlled 1 | Homo sapiens | NP_003286 | IgE-dependent histamine-releasing factor |
| 77H04 | SEC61, γ subunit of protein translocation complex | Mus musculus | XP_122171 | Protein translocation |
| 09G06 | Ferritin heavy chain | Salmo salar | P49946 | Iron storage and cellular regulation |
| 47B04 | Ferritin H-3 | Oncorhynchus mykiss | BAA13148 | Iron storage and cellular regulation |
| 91F11 | Ferritin light chain 2 | Mus musculus | NP_032075 | Iron storage and cellular regulation |