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Transcriptional profile of PS-341-treated MM-1S cells by oligonucleotide-microarray analysis. Representative functional clusters of transcriptional changes induced by PS-341 (100 nM, 1–8 h) include molecules implicated in caspase-mediated apoptosis, growth factor signaling and cell cycle control, heat shock proteins, and proteasome subunits. Color saturation is proportional to magnitude of the difference from the respective control.
