Skip to main content
PMC home page
Gut logoLink to Gut
. 1991 Jul;32(7):813–818. doi: 10.1136/gut.32.7.813

Glutathione S-transferase in humans in health and disease.

P C Hayes 1, I A Bouchier 1, G J Beckett 1
PMCID: PMC1379001  PMID: 1855690

Full text

PDF
814

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adachi Y., Horii K., Takahashi Y., Tanihata M., Ohba Y., Yamamoto T. Serum glutathione S-transferase activity in liver diseases. Clin Chim Acta. 1980 Oct 9;106(3):243–255. doi: 10.1016/0009-8981(80)90308-3. [DOI] [PubMed] [Google Scholar]
  2. Bach M. K., Brashler J. R., Morton D. R., Jr Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase. Arch Biochem Biophys. 1984 May 1;230(2):455–465. doi: 10.1016/0003-9861(84)90426-0. [DOI] [PubMed] [Google Scholar]
  3. Beckett G. J., Boyd R., Beddows S. E., Hayes J. D. Decreased hepatic glutathione S-transferase A, AA and L concentration produced by prolonged thyroid hormone administration. Biochem Pharmacol. 1988 Aug 15;37(16):3201–3204. doi: 10.1016/0006-2952(88)90322-x. [DOI] [PubMed] [Google Scholar]
  4. Beckett G. J., Chapman B. J., Dyson E. H., Hayes J. D. Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage. Gut. 1985 Jan;26(1):26–31. doi: 10.1136/gut.26.1.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Beckett G. J., Foster G. R., Hussey A. J., Oliveira D. B., Donovan J. W., Prescott L. F., Proudfoot A. T. Plasma glutathione S-transferase and F protein are more sensitive than alanine aminotransferase as markers of paracetamol (acetaminophen)-induced liver damage. Clin Chem. 1989 Nov;35(11):2186–2189. [PubMed] [Google Scholar]
  6. Beckett G. J., Hayes J. D. Development of specific radioimmunoassays for the measurement of human hepatic basic and N/A2b glutathione S-transferases. Clin Chim Acta. 1984 Aug 31;141(2-3):267–273. doi: 10.1016/0009-8981(84)90020-2. [DOI] [PubMed] [Google Scholar]
  7. Beckett G. J., Hayes P. C., Hussey A. J., Bouchier I. A., Hayes J. D. Plasma glutathione S-transferase measurements in patients with alcoholic cirrhosis. Clin Chim Acta. 1987 Oct 30;169(1):85–89. doi: 10.1016/0009-8981(87)90396-2. [DOI] [PubMed] [Google Scholar]
  8. Beckett G. J., Hussey A. J., Laing I., Howie A. F., Hayes J. D., Strange R. C., Faulder C. G., Hume R. Measurements of glutathione S-transferase B1 in plasma after birth asphyxia: an early indication of hepatocellular damage. Clin Chem. 1989 Jun;35(6):995–999. [PubMed] [Google Scholar]
  9. Beckett G. J., Kellett H. A., Gow S. M., Hussey A. J., Hayes J. D., Toft A. D. Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):427–431. doi: 10.1136/bmj.291.6493.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Board P. G. Biochemical genetics of glutathione-S-transferase in man. Am J Hum Genet. 1981 Jan;33(1):36–43. [PMC free article] [PubMed] [Google Scholar]
  11. Brown B. R., Jr, Gandolfi A. J. Adverse effects of volatile anaesthetics. Br J Anaesth. 1987 Jan;59(1):14–23. doi: 10.1093/bja/59.1.14. [DOI] [PubMed] [Google Scholar]
  12. CALVERT D. N., BRODY T. M. The effects of thyroid function upon carbon tetrachloride hepatotoxicity. J Pharmacol Exp Ther. 1961 Dec;134:304–310. [PubMed] [Google Scholar]
  13. Christ-Hazelhof E., Nugteren D. H., Van Dorp D. A. Conversions of prostaglandin endoperoxides by glutathione-S-transferases and serum albumins. Biochim Biophys Acta. 1976 Dec 20;450(3):450–461. doi: 10.1016/0005-2760(76)90018-7. [DOI] [PubMed] [Google Scholar]
  14. Di Ilio C., Del Boccio G., Aceto A., Casaccia R., Mucilli F., Federici G. Elevation of glutathione transferase activity in human lung tumor. Carcinogenesis. 1988 Feb;9(2):335–340. doi: 10.1093/carcin/9.2.335. [DOI] [PubMed] [Google Scholar]
  15. Eimoto H., Tsutsumi M., Nakajima A., Yamamoto K., Takashima Y., Maruyama H., Konishi Y. Expression of the glutathione S-transferase placental form in human lung carcinomas. Carcinogenesis. 1988 Dec;9(12):2325–2327. doi: 10.1093/carcin/9.12.2325. [DOI] [PubMed] [Google Scholar]
  16. Farrell G., Prendergast D., Murray M. Halothane hepatitis. Detection of a constitutional susceptibility factor. N Engl J Med. 1985 Nov 21;313(21):1310–1314. doi: 10.1056/NEJM198511213132102. [DOI] [PubMed] [Google Scholar]
  17. Gow S. M., Caldwell G., Toft A. D., Beckett G. J. Different hepatic responses to thyroxine replacement in spontaneous and 131I-induced primary hypothyroidism. Clin Endocrinol (Oxf) 1989 May;30(5):505–512. doi: 10.1111/j.1365-2265.1989.tb01421.x. [DOI] [PubMed] [Google Scholar]
  18. Gow S. M., Caldwell G., Toft A. D., Seth J., Hussey A. J., Sweeting V. M., Beckett G. J. Relationship between pituitary and other target organ responsiveness in hypothyroid patients receiving thyroxine replacement. J Clin Endocrinol Metab. 1987 Feb;64(2):364–370. doi: 10.1210/jcem-64-2-364. [DOI] [PubMed] [Google Scholar]
  19. Gow S. M., Caldwell G., Toft A. D., Sweeting V. M., Beckett G. J. Restoration of normal thyrotrophin secretion reduces the abnormally high serum glutathione S-transferase levels found in patients receiving thyroxine replacement therapy. Clin Endocrinol (Oxf) 1988 Sep;29(3):249–256. doi: 10.1111/j.1365-2265.1988.tb01222.x. [DOI] [PubMed] [Google Scholar]
  20. Harada S., Abei M., Tanaka N., Agarwal D. P., Goedde H. W. Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance. Hum Genet. 1987 Apr;75(4):322–325. doi: 10.1007/BF00284101. [DOI] [PubMed] [Google Scholar]
  21. Hayes P. C., Harrison D. J., Bouchier I. A., McLellan L. I., Hayes J. D. Cytosolic and microsomal glutathione S-transferase isoenzymes in normal human liver and intestinal epithelium. Gut. 1989 Jun;30(6):854–859. doi: 10.1136/gut.30.6.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hayes P. C., Hussey A. J., Keating J., Bouchier I. A., Williams R., Beckett G. J., Hayes J. D. Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase. Clin Chim Acta. 1988 Mar 15;172(2-3):211–216. doi: 10.1016/0009-8981(88)90325-7. [DOI] [PubMed] [Google Scholar]
  23. Hiley C., Fryer A., Bell J., Hume R., Strange R. C. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochem J. 1988 Aug 15;254(1):255–259. doi: 10.1042/bj2540255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Howie A. F., Douglas J. G., Fergusson R. J., Beckett G. J. Measurement of glutathione S-transferase pi isoenzyme in plasma, a possible marker for adenocarcinoma of the lung. Clin Chem. 1990 Mar;36(3):453–456. [PubMed] [Google Scholar]
  25. Howie A. F., Forrester L. M., Glancey M. J., Schlager J. J., Powis G., Beckett G. J., Hayes J. D., Wolf C. R. Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues. Carcinogenesis. 1990 Mar;11(3):451–458. doi: 10.1093/carcin/11.3.451. [DOI] [PubMed] [Google Scholar]
  26. Howie A. F., Hayes J. D., Beckett G. J. Purification of acidic glutathione S-transferases from human lung, placenta and erythrocyte and the development of a specific radioimmunoassay for their measurement. Clin Chim Acta. 1988 Sep 30;177(1):65–75. doi: 10.1016/0009-8981(88)90308-7. [DOI] [PubMed] [Google Scholar]
  27. Howie A. F., Hayes P. C., Bouchier I. A., Hayes J. D., Beckett G. J. Glutathione S-transferase in human bile. Clin Chim Acta. 1989 Oct 16;184(3):269–278. doi: 10.1016/0009-8981(89)90060-0. [DOI] [PubMed] [Google Scholar]
  28. Howie A. F., Miller W. R., Hawkins R. A., Hutchinson A. R., Beckett G. J. Expression of glutathione S-transferase B1, B2, Mu and Pi in breast cancers and their relationship to oestrogen receptor status. Br J Cancer. 1989 Dec;60(6):834–837. doi: 10.1038/bjc.1989.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hussey A. J., Aldridge L. M., Paul D., Ray D. C., Beckett G. J., Allan L. G. Plasma glutathione S-transferase concentration as a measure of hepatocellular integrity following a single general anaesthetic with halothane, enflurane or isoflurane. Br J Anaesth. 1988 Feb;60(2):130–135. doi: 10.1093/bja/60.2.130. [DOI] [PubMed] [Google Scholar]
  30. Hussey A. J., Hayes J. D., Beckett G. J. The polymorphic expression of neutral glutathione S-transferase in human mononuclear leucocytes as measured by specific radioimmunoassay. Biochem Pharmacol. 1987 Nov 15;36(22):4013–4015. doi: 10.1016/0006-2952(87)90472-2. [DOI] [PubMed] [Google Scholar]
  31. Hussey A. J., Hayes J. D., Beckett G. J. The polymorphic expression of neutral glutathione S-transferase in human mononuclear leucocytes as measured by specific radioimmunoassay. Biochem Pharmacol. 1987 Nov 15;36(22):4013–4015. doi: 10.1016/0006-2952(87)90472-2. [DOI] [PubMed] [Google Scholar]
  32. Hussey A. J., Howie J., Allan L. G., Drummond G., Hayes J. D., Beckett G. J. Impaired hepatocellular integrity during general anaesthesia, as assessed by measurement of plasma glutathione S-transferase. Clin Chim Acta. 1986 Nov 30;161(1):19–28. doi: 10.1016/0009-8981(86)90259-7. [DOI] [PubMed] [Google Scholar]
  33. Kodate C., Fukushi A., Narita T., Kudo H., Soma Y., Sato K. Human placental form of glutathione S-transferase (GST-pi) as a new immunohistochemical marker for human colonic carcinoma. Jpn J Cancer Res. 1986 Mar;77(3):226–229. [PubMed] [Google Scholar]
  34. Mannervik B., Danielson U. H. Glutathione transferases--structure and catalytic activity. CRC Crit Rev Biochem. 1988;23(3):283–337. doi: 10.3109/10409238809088226. [DOI] [PubMed] [Google Scholar]
  35. Mannervik B. The isoenzymes of glutathione transferase. Adv Enzymol Relat Areas Mol Biol. 1985;57:357–417. doi: 10.1002/9780470123034.ch5. [DOI] [PubMed] [Google Scholar]
  36. Meyer D. J., Beale D., Tan K. H., Coles B., Ketterer B. Glutathione transferases in primary rat hepatomas: the isolation of a form with GSH peroxidase activity. FEBS Lett. 1985 May 6;184(1):139–143. doi: 10.1016/0014-5793(85)80670-0. [DOI] [PubMed] [Google Scholar]
  37. Morgenstern R., DePierre J. W. Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition. Eur J Biochem. 1983 Aug 15;134(3):591–597. doi: 10.1111/j.1432-1033.1983.tb07607.x. [DOI] [PubMed] [Google Scholar]
  38. Morgenstern R., Guthenberg C., Depierre J. W. Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C. Eur J Biochem. 1982 Nov;128(1):243–248. [PubMed] [Google Scholar]
  39. Neuberger J., Williams R. Halothane anaesthesia and liver damage. Br Med J (Clin Res Ed) 1984 Oct 27;289(6452):1136–1139. doi: 10.1136/bmj.289.6452.1136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Niitsu Y., Takahashi Y., Saito T., Hirata Y., Arisato N., Maruyama H., Kohgo Y., Listowsky I. Serum glutathione-S-transferase-pi as a tumor marker for gastrointestinal malignancies. Cancer. 1989 Jan 15;63(2):317–323. doi: 10.1002/1097-0142(19890115)63:2<317::aid-cncr2820630219>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  41. Pour P. M. Mechanism of pseudoductular (tubular) formation during pancreatic carcinogenesis in the hamster model. An electron-microscopic and immunohistochemical study. Am J Pathol. 1988 Feb;130(2):335–344. [PMC free article] [PubMed] [Google Scholar]
  42. Seidegård J., Pero R. W., Markowitz M. M., Roush G., Miller D. G., Beattie E. J. Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis. 1990 Jan;11(1):33–36. doi: 10.1093/carcin/11.1.33. [DOI] [PubMed] [Google Scholar]
  43. Sheridan P. Thyroid hormones and the liver. Clin Gastroenterol. 1983 Sep;12(3):797–818. [PubMed] [Google Scholar]
  44. Sherman M., Bass N. M., Campbell J. A., Kirsch R. E. Radioimmunoassay of human ligandin. Hepatology. 1983 Mar-Apr;3(2):162–169. doi: 10.1002/hep.1840030205. [DOI] [PubMed] [Google Scholar]
  45. Singh S. V., Leal T., Awasthi Y. C. Inhibition of human glutathione S-transferases by bile acids. Toxicol Appl Pharmacol. 1988 Sep 15;95(2):248–254. doi: 10.1016/0041-008x(88)90161-5. [DOI] [PubMed] [Google Scholar]
  46. Stockman P. K., Beckett G. J., Hayes J. D. Identification of a basic hybrid glutathione S-transferase from human liver. Glutathione S-transferase delta is composed of two distinct subunits (B1 and B2). Biochem J. 1985 Apr 15;227(2):457–465. doi: 10.1042/bj2270457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Tsuchida S., Sekine Y., Shineha R., Nishihira T., Sato K. Elevation of the placental glutathione S-transferase form (GST-pi) in tumor tissues and the levels in sera of patients with cancer. Cancer Res. 1989 Sep 15;49(18):5225–5229. [PubMed] [Google Scholar]
  48. Wood M., Berman M. L., Harbison R. D., Hoyle P., Phythyon J. M., Wood A. J. Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. Anesthesiology. 1980 Jun;52(6):470–476. doi: 10.1097/00000542-198006000-00003. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES