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Linkage of the modifier to chromosome 1. (a) A genome scan of the Notch-severe and Notch-mild mice mapped a modifier of the Notch phenotype to distal chromosome 1. Genetic analysis of the locus showed the maximum LOD score was 6.1, identified by D1Mit150 at position 100-cM. (b) Physical definition of the modifier confidence interval showing placement of Nicastrin and PS2.
