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. 2002 Oct 21;99(22):14560–14565. doi: 10.1073/pnas.222348099

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Copyright © 2002, The National Academy of Sciences

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Fig 2. — Blockade of MaxiK channels decreases the vasorelaxing effect of PP2 in rat aorta. (A) Cumulative dose response of 5-HT-precontracted rings with PP2 (numbers are PP2 concentration in micromolar). (B) Preincubation with 100 nM IbTx for ≈25 min diminished the efficacy of PP2 to relax aortic rings. (C) Dose–response curves of PP2-induced relaxation ± 100 nM IbTx. Continuous lines are the best fit to a Hill function. (D) Mean percentage relaxation by 10 μM PP2 with or without (control) 100 nM IbTx in rings precontracted with 2 μM 5-HT (110 ± 3, n = 8 vs. 37 ± 6% relaxation, n = 6), 100 nM AngII (58 ± 10, n = 6 vs. 10 ± 4% relaxation, n = 5), or 2 μM phenylephrine (Phe) (56 ± 8, n = 9 vs. 13 ± 3% relaxation, n = 7); *, P < 0.005.