Figure 2.

Coding joints facilitated by the G4122E mutant DNA-PKcs are structurally normal. The sequence of coding ends and heptamers, as they are in the pJH290 substrate, are shown above the sequences of the recombinant junctions. Numbers to the right of sequences indicate the number of observations of that sequence. ‘P’ denotes palindromic nucleotides added to each junction. Nucleotides that cannot unequivocally be assigned to a particular coding end are underlined and listed in the more 5′ location.