Table 1.
Excluded from the criteria independent of disease or condition: | |
Because the drugs were unavailable in Japan | |
Propoxyphene | Hyoscyamine |
Trimethobenzamide | Tripelennamine |
Carisoprodol | Dexchlorpheniramine |
Medaxalone | Cyclandelate |
Cyclobenzaprine | Meperidine |
Chlordiazepoxide-amitriptyline | Ketorolac |
Perphenazine-amitriptyline | Daily fluoxetine |
Doxepine | Orphenadrine |
Meprobamate | Guanethidine |
Oxazepam | Guanadrel |
Temazepam | Nitrofurantoin |
Clidinium-chlordiazepoxide | Mesoridazine |
Halazepam | Mineral oil |
Chlorazepate | Amphetamines (excluding methylphenidate hydrochloride and anorexics) |
Because long-term use could not be tracked | |
Long-term use of full-dosage, longer-half life, non-COX-selective NSAIDs | |
Long-term use of stimulant laxatives | |
Excluded from the criteria dependent on disease or condition: | |
Because the drug was unavailable in Japan | |
Seizure disorder (Bupropion was unavailable.) | |
Because the patients with these disease or conditions could not be identified | |
Gastric or duodenal ulcers | SIADH/hyponatremia |
Bladder outflow obstruction |