. 2002 Dec 1;30(23):5160–5167. doi: 10.1093/nar/gkf651

Table 1. Oligomer sequence, T_m values and inhibition of luciferase activity data for LNAs and LNA–DNA chimeras that target the 5′-UTR of luciferase mRNA.

ID	Sequence 5′→3′	T_m (°C) DNA:DNA	T_m (°C) LNA:DNA	Inhibition (%)
				25 nM	100 nM	200 nM
I	AgggTcGcTCGGT	66	ND	50	63	76
II	AgggTcGcTCAAT	51	65	0	0	21
III	ACACCGAGcGacccT	71	ND	0	0	0
IV	AgggTcGcTCGGTgT	71	ND	69	80	95
V	AgggTcGcTCAATgT	66	83	20	19	21
VI	AGGGTCGCTCGGTGT	66	ND	76	83	93
VII	TAaGcggGTcGcTGC	66	86	28	36	48
VIII	AGGGtcgctcgGTGT	71	78	33	74	81
IX	TCGAgatctgcGGCA	64	68	11	22	25
X	TTACcaacagtACCG	54	71	0	0	5

Capitalized letters within a sequence represent LNA bases, lower case letters represent DNA bases and underlined bases depict mismatches relative to the mRNA target. ND, T_m not determined because it was too high to accurately measure.

Table 1. Oligomer sequence, Tm values and inhibition of luciferase activity data for LNAs and LNA–DNA chimeras that target the 5′-UTR of luciferase mRNA.

Table 1. Oligomer sequence, T_m values and inhibition of luciferase activity data for LNAs and LNA–DNA chimeras that target the 5′-UTR of luciferase mRNA.