Table 1.

Conventionally fractionated radiotherapy with or without simultaneous chemotherapy using cisplatin, carboplatin, mitomycin C, and 5-FU as single drug or combinations of 5-FU with platinum-derivate (group 1a)

		control arm		experimental arm
publication	trial #	dose [Gy]	RT time [days]	dose [Gy]	RT time [days]	DDP	Carbo	5-FU	FA	MMC	stage 4 [%]	neck N3 [%]
Sanchiz [18]	1	60	42.0	60	42.0			3750				30
Lo [24]	2	66	56.0	66	56.0			5500			41	38
Browman [25]	3	66	45.5	66	45.5			7200			55	14
Jerimic [26]	4	70	50.8	70	50.8	222					86	16
Adelstein [27]	5	70	49.0	70	49.0	300					94	28
Jeremic [26]	6	70	50.8	70	50.8		925				86	19
Grau [28]	7	66	47.0	66	47.0					30	53	4
Adelstein [29]	8	70	49.0	70	49.0	160		8000			72	31
Olmi [30]	9	68	47.3	68	47.25		900	12000			75	7
Denis, Calais [31,32]	10	70	49.0	70	49.0		840	7200			68	13

DDP = cisplatin cumulative dose [mg/m²]; Carbo = carboplatin cumulative dose [mg/m²]; 5-FU = 5-fluorouracil cumulative dose [mg/m²]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m²]