Table 4.

Comparison of accelerated or hyperfractionated radiotherapy with conventionally fractionated radiotherapy (Group 2/3)

		control arm		experimental arm
publication	trial #	dose [Gy]	RT time [days]	dose [Gy]	RT time [days]	fractionation	Stage 4 [%]	N3 [%]
group 2		conventional fract.		acceleration
Dische [16]	20	66	45.5	54	12	CHART	72	6
Dobrowsky [37]	21	70	49.0	55.3	17	CHART		12
Olmi [41]	22	68	47.3	65.6	42.7	AF split	70	7
Fu [42]	23	70	49.0	67.2	43.4	AF split	68	13
v. den Bogaert [43]	24	72.5	56.0	69.6	44.8	AF split	65	47
Horiot [23]	25	70	51.7	72	35	AF split	0	0
Fu [42]	26	70	49.0	72	42	concomittant boost
Overgaard [44]	27	66–68	39.0	66–68	46.0	weekend	25
Skladowsky [13]	28	70.6	54	70.75	40	weekend	17	0
group 3		conventional fract.		hyperfractionation
Sanchiz [18]	29	60	42.0	70.4	44.8	HFX		30
Pinto [45]	30	66	46.2	70.4	44.8	HFX	54	25
Horiot [46]	31	70	51.1	80.5	49	HFX		15
Fu [42]	32	70	49.0	81.6	47.6	HFX	68	13