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Top and middle panels, Proband (IV:7) demonstrating generalized hypopigmentation and iris transillumination on slit-lamp examination. Lower panel, Transmission electron micrograph of skin sample from the proband. Fully melanized melanosomes (arrowheads) are evident in the cytoplasm of a melanocyte (M) and in large membrane-enclosed aggregates (arrows) in an adjacent basal keratinocyte (K). D = superficial dermis. Magnification bar 1 μm.
