Figure 2.

Transcript map of the critical DNA region for CLD. The physical map was constructed using public (International Human Genome Sequencing Consortium) Human Genome Project annotations. Evidence for transcripts and for conserved amino acids was searched with BLAST against different databases, including the dbEST and Refseq protein databases. Complete sequence annotations were performed by the NIX program (UK Human Genome Mapping Project Resource Centre) and the UCSC Genome Browser. LCT, minichromosome maintenance deficient 6 (MCM6 [MIM 601806]), aspartyl-tRNA synthetase (DARS [MIM 603084]), chemokine receptor type 4 (CXCR4 [MIM 162643]), and KIAA1679 are the known genes in the region (horizontal arrows). The mouse ortholog (BC063250) of human KIAA1679 suggests that ESTs BX954188 and BX954180 may be related to transcripts of KIAA1679. Microsatellite markers are indicated by vertical arrows. The centromere is on the left.