Table 5.
Demographic Characteristics of DHS Blacks With and Without LDL-Lowering Nonsynonymous Variations in PCSK9[Note]
|
LDL-LoweringNonsynonymous SequenceVariationsa |
||
| Characteristic | Blacks Without | Blacks With |
| Total no. of subjects | 1,423 | 354 |
| No. (%) of men | 601 (42) | 150 (42) |
| Age (years) | 44.9 ± 10.3 | 44.1 ± 10.1 |
| BMI | 32 ± 8.12 | 31.8 ± 7.73 |
| No. (%) of diabetics | 286 (20) | 70 (20) |
| Cholesterol (mg/dl) | 179 ± 39.3 | 172 ± 36.1b |
| Triglyceride (mg/dl)c | 88 (58) | 91 (60) |
| LDL-C (mg/dl) | 106 ± 35.9 | 97.3 ± 34.5d |
| HDL-C (mg/dl) | 52 ± 14.9 | 53.4 ± 16.3 |
| VLDL-C (mg/dl)c | 17 (11) | 18 (12) |
| HTGC (%)c | 3.2 (3.2) | 3.2 (3.0) |
Note.— Values were compared between subjects without and subjects with a nonsynonymous sequence variation in PCSK9 that was significantly associated with decreased plasma LDL-C level in the DHS blacks (Y142X, L253F, A443T, and C679X). All lipoprotein levels and BMIs were adjusted for age and sex by linear regression. Percentages were compared by two-sided Fisher’s exact test, means were compared by two-sided Welch t test, and medians were compared by two-sided Wilcoxon rank sum test.
a
Data are mean ± SD unless otherwise indicated.
b
P<.01.
c
Data are median (interquartile range).
d
P<.001.