Table 1.
TRF Length Heritability Model Estimates[Note]
|
Heritability Estimates |
||||||||||||
| A |
C/D |
E |
Fit Statistics |
|||||||||
| Estimate and Model | a2 | 95% CI | c2 | d2 | 95% CI | e2 | 95% CI | No. ofEstimatedParameters | −2 LL | Δ χ2 | Δ df | P |
| TRF Length: | ||||||||||||
| ACE | .33 | .17–.44 | .53 | … | .50–.62 | .14 | .10–.21 | 6 | 3,323 | … | … | … |
| ADE | .91 | .89–.93 | … | 0 | .00–.02 | .09 | .07–.11 | 6 | 3,486 | … | … | … |
| CE | … | .71 | … | .70–.74 | .29 | .26–.32 | 5 | 3,334 | 11 | 1 | .001 | |
| AE | .91 | .89–.93 | … | … | … | .09 | .07–.11 | 5 | 3,486 | 163 | 1 | 0 |
| TRF Length and covariates: | ||||||||||||
| ACE | .36 | .18–.48 | .49 | … | .40–.58 | .16 | .11–.24 | 6 | 3,088 | … | … | … |
| ADE | .9 | .87–.92 | … | 0 | .00–.02 | .1 | .08–.13 | 6 | 3,195 | … | … | … |
| CE | … | … | .67 | … | .64–.7 | .33 | .30–.36 | 5 | 3,099 | 11 | 1 | .001 |
| AE | .9 | .87–.92 | … | … | … | .1 | .08–.13 | 5 | 3,195 | 107 | 1 | 0 |
Note.— All models include age as a covariate and use the residuals of raw TRF length, adjusted for experimental batch effects. Additional covariates are BMI and smoking history (never, current, or former smoker). A = additive polygenic effects; C = familial common environment; D = dominance effects; E = specific individual effects and measurement error. A, C, D, and E are variance components terms; a, c, d, and e refer to the standard deviation. Model-fit statistics for models CE and AE are presented as submodels of ACE. The best-fit models are highlighted in bold italics.