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A, Response of mesenteric branch arteries isolated from CB1+/+ and CB1−/− mice to the cumulative addition of extracellular Ca2+ after precontraction with 5 μmol/L NE. Values are mean± SEM, n=6; no significant differences were detected. Effect of 0.3 and 1.0 μmol/L SR141716A on Ca2+-induced relaxation of mesenteric branch arteries isolated from CB1−/− mice (B) and wild-type control mice (C). Values are mean± SEM, n=4 to 6. *P<0.05 between points.
