Figure 1.

Schematic of the sensitization protocol. Sensitized mice were challenged with 1% (wt/vol) ovalbumin for 30 min on days 21–23. Groups of mice were exposed to 2 ppm ozone for 8 h per day for 4, 8, and 12 weeks, respectively. Whole-body plethysmography was performed at 24 days and at 8, 12, and 16 weeks. Broncholalveolar lavage fluid and lung tissue were obtained at 24 days and at 8, 12, and 16 weeks.