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. 2006 Feb 13;7(1):24. doi: 10.1186/1465-9921-7-24

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Copyright © 2006 Jang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Bronchioles exposed to filtered air have normal-appearing bronchioles and bronchiolo-alveolar portal and a normal transition from the low columnar epithelium lining the terminal bronchioles to the attenuated epithelium lining the alveoli. (B–D) Bronchioles exposed to 2 ppm ozone for 4, 8, and 12 weeks. (B) Pseudostratified bronchiolar epithelium and goblet cell metaplasia. (C)Markedly increased number of goblet cells. (D) Peribronchiolar collagen deposition and thickened smooth muscle cell coat. Original magnification, ×200. Scale bar = 100 μm.