Ionomycin-evoked currents (Vh = − 50 mV) were significantly inhibited by niflumic acid (0.1 mm) in HEK293 cells expressing mCLCA5 (n = 7, p = 0.0004, t test), mCLCA6 (n = 7, p < 0.0001), and the mCLCA6 splice variant (mCLCA6sv) (n = 7, p < 0.0001) but not in untransfected (n = 10, p = 0.97) or mock-transfected (n = 4, p = 0.47, not shown) control cells.