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. 2006 Jan 12;25(2):312–322. doi: 10.1038/sj.emboj.7600940

Figure 5.

Figure 5

Gustatory plasticity requires cGMP. (A) Salt detection was not affected in daf-11 animals (P>0.05), but significantly impaired in tax-2 and tax-4 animals (P<0.01 at 1 and 10 mM NaCl). These mutants still responded to 100 mM NaCl. (B) Mutation of gcy-35 affected gustatory plasticity (P<0.001). This defect could be rescued by expression of gcy-35 in the AQR, PQR and URX neurons (P<0.0001). Expression of a gcy-32∷egl-2(gf) construct to inhibit the activity of AQR, PQR and URX neurons reduced avoidance after pre-exposure (P<0.05). Analysis of a gpc-1 gcy-35 double-mutant strain indicated that these genes function in the same genetic pathway in gustatory plasticity (P>0.05 compared to the single mutants). (C) Mutation of the cGMP signalling molecules egl-4 (P<0.001) and pdl-1 (P<0.01) affected gustatory plasticity, whereas mutation of gcy-32 did not (P>0.05).