Table 2.

Pattern of V_H 3′-flanking mutations in SMUG1-transgenic mice

Mice	n	Age (months)	Sequences		Mutationsa
			Total (n)	Mutated (%)	Total (n)	% at G:C	% Tvnsb	% at A:T
ung+/+
Control	4	11–14	149	62	1169	42	47	57
hSMUG1	4	11–14	153	43	468	40	46	60
ung−/−
Control	3	9	214	66	1363	50	7	43
hSMUG1	1	9	37	40	112	40	11	60
hSMUG1	2	3.5	90	17	27	55	20	45
msh2−/−/ung−/−
Control	2	5–6	148	65	520	98	0.2	2
hSMUG1	3	5	232	61	100	75	28	25
aThe stringent criteria described by Rada et al (2004) were used to avoid repeat counting of mutations in dynastically related sequences.
bThe percentage of substitutions at C:G base pairs that are nucleotide transversions.