Figure 2.
Structure of the putative CCR5-binding region of RANTES. Molecular surface representation (by GRASP) of the NMR solution structure of the RANTES dimer showing a large hydrophobic surface, lined by charged residues, where critical amino acids for CCR5 interaction and anti-HIV activity were mapped. Blue denotes positive electrical charge; red, negative charge; white, no charge (adapted from Nardese et al, 2001).