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. 2006 Jan 26;25(3):512–521. doi: 10.1038/sj.emboj.7600961

Figure 8.

Figure 8

Model for heme regulation of FET3 and ARN1 expression. Under normal heme conditions, Aft1p binds to the promoters of both FET3 and ARN1, leading to the recruitment of Tup1p and Cti6p. Under low-iron conditions in the absence of heme, Tup1p is able to mediate repression of FET3 through the chromatin remodeling protein Hda1p. The sequence immediately downstream of the Aft1p binding site of ARN1 mediates retention of Cti6p under heme-depleted conditions, resulting in loss of Tup1p and expression of ARN1.