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. 2005 Dec 12;393(Pt 1):381–387. doi: 10.1042/BJ20051133

Figure 8. E. coli MutY may have a role in preventing the mutagenic effects of hoU.

Figure 8

hoU in DNA can be derived from oxidation, deamination and dehydration of cytosine. The Endo VIII glycosylase/AP lyase removes hoU adducts. When hoU/G is not repaired by Endo VIII, adenines are frequently incorporated opposite hoU bases during DNA replication. A/hoU mismatches may be repaired to G/hoU by the MutY pathway. Without repair, the second round of DNA replication of A/hoU can generate G:C→A:T transitions. If Endo VIII repairs an A/hoU mismatch when hoU is on the parental DNA strand, a G:C→A:T mutation occurs. MutY may inhibit Endo VIII repair on A/hoU. Bases on the daughter DNA strands are circled. Repair pathways that can reduce mutagenesis are marked with solid thick lines.