Table 1.
Effect Sizes for Cognitive Allelic Association Studies
Gene | Allele With Cognitive Effects | Task | fa | Source of Data |
---|---|---|---|---|
ApoE | ε4 | (a) cued discrimination (b) word pair recall, digit symbol | (a) .14 (b) .42 | (a) Greenwood, Sunderland, Friz, and Parasuraman, 2000 (b) Flory, Manuck, Ferrell, Ryan, and Muldoon, 2000 |
BDNF Val66met | met | (a) WMSb delayed recall (b) scene recognition | (a) .26 (b) .46 | (a) Egan et al., 2003 (b) Hariri et al., 2003 |
COMT val158met | met | (a) WCSTc (b) processing speed/attention | (a) .41 (b) .42 | (a) Egan et al., 2001 (b) Bilder et al., 2002 |
DBH G444A | A | memory for location | .19 | Greenwood, Fossella, and Parasuraman, 2003 |
DRD4 exon 3 VNTR | 7-repeat | (a)attentional orienting (b) RT | .29 | (a) Fossella et al., 2002 (b)Swanson et al., 2000 |
DRD1 A-48G | G | novelty seeking questionnaire | .68 | Limosin, Loze, Rouillon, Ades, and Gorwood, 2003 |
CHRNA4 C1545T | both? | cued discrimination | .30 | Greenwood et al., 2003 |
Cohen's method for unequal sample sizes (Cohen, 1988).
WMS = Wechsler Memory Scale.
WCST = Wisconsin Card Sort Test.