Fig 3.

A molscript (56, 57) diagram of the CBD of sIL-6R viewed from the top of Fig. 1 showing the IL-6 binding loops L1–L7. The side chains of the loops are shown as ball and stick representations, and the remaining structure is shown as in Fig. 1. The IL-6-binding loops are represented by a backbone worm representation colored red (L1), yellow (L2), green (L3), cyan (L4), pink (L5), dark green (L6), and orange (L7), respectively. The side-chain bonds are color matched to the respective loops. Oxygen, nitrogen, and sulfur atoms in the loop side chains are colored as red, blue, and yellow spheres, respectively (57). The cysteinyl-cysteine C192 is also shown on loop L4.