Effect of GPA treatment on mitochondrial content assessed by electron microscopy of the epitrochlearis (EPI) muscle of (a) WT mouse (saline treated), (b) WT mouse (GPA treated), (c) DN-AMPK transgenic mouse (saline treated), and (d) DN-AMPK transgenic mouse (GPA treated). Arrows point to mitochondria. (Bar, 1 μm.) (e) Mitochondria density (% of total volume) in the extensor digitorum longus (EDL; n = 10 in each group) and EPI muscles of each group mice (n = 5 in each group). *, P < 0.05 compared with other groups.