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CHF1 knockout mice have ventricular septal defects but no other organ pathology. (a) Transverse section through thorax of knockout and wild-type mouse at E13.5 and E14.5. KO, knockout; WT, wild type; LV, left ventricle; RV, right ventricle. *, VSD. Note that ventricular septation was completed in E14.5 wild-type mouse (arrow). (b) Sagittal section of E18.5 knockout mouse. Morphological structure of brain, lung, liver, kidney, intestines, and other organs appeared normal.
