Table 2.
Echocardiography of CHF1 knockout mice
| Wild type | CHF1 −/− | P value | |
|---|---|---|---|
| Number | 9 | 7 | – |
| Age, weeks | 17.9 ± 1.2 | 17.9 ± 0.63 | NS |
| HR, bpm | 613 ± 97 | 600 ± 62 | NS |
| WThd, mm | 1.01 ± 0.79 | 1.03 ± 0.94 | NS |
| LVDs, mm | 1.81 ± 0.44 | 3.20 ± 0.96 | <0.01 |
| LVDd, mm | 3.21 ± 0.47 | 4.07 ± 0.86 | <0.05 |
| FS | 0.44 ± 0.12 | 0.22 ± 0.14 | <0.01 |
| Calc (N/Mi/Mo/S) | 7/2/0/0 | 0/0/3/4 | <0.01 |
Results were expressed as mean value ± SD, if applicable. Statistical analysis was performed by using an unpaired Student's t test for age, HR, WThd, LVDs, and FS, and a Mann–Whitney U test for calcification. A P value of <0.05 was considered statistically significant. Abbreviations: HR, heart rate; bpm, beats per minute; WThd, diastolic wall thickness; LVDs, systolic left ventricular dimension; LVDd, diastolic left ventricular dimension; FS, fractional shortening; Calc, grade of subendocardial calcification; N/Mi/Mo/S, none/mild/moderate/severe; NS, not significant.