Table 2. Antibacterial and antifungal activities of HP (2-20) and its analogues.
MIC [μM] | |||||||||
---|---|---|---|---|---|---|---|---|---|
ME* | HP† | A1 | A2 | A3 | A4 | A5 | A6 | A7 | |
Bacteria | |||||||||
B. subtilis | 0.78 | 3.13 | 1.56 | 1.56 | 1.56 | 6.25 | 3.13 | 1.56 | 1.56 |
S. epidermidis | 3.13 | 6.25 | 3.13 | 3.13 | 3.13 | >12.5 | 12.5 | 6.25 | 3.13 |
S. aureus | 0.78 | 12.5 | 3.13 | 6.25 | 1.56 | >12.5 | >12.5 | 3.13 | 3.13 |
E. coli | 0.78 | 3.13 | 0.78 | 3.13 | 1.56 | 12.5 | 6.25 | 3.13 | 3.13 |
S. typhimurium | 0.39 | 1.56 | 0.39 | 0.78 | 0.39 | 12.5 | 12.5 | 0.39 | 0.39 |
P. vulgaris | 1.56 | 6.25–3.13 | 3.13 | 3.13 | 3.13 | >12.5 | >12.5 | 3.125 | 6.25–3.13 |
P. aeruginosa | 3.13 | 6.25 | 3.13 | 6.25 | 3.13 | 12.5 | 12.5 | 6.25 | 3.13 |
E. coli O157 | 3.13 | 12.5 | 6.25 | 6.25 | 3.13 | >12.5 | 6.25 | 6.25 | 3.13 |
L. monocytogenes | 0.39 | 6.25 | 0.78 | 1.56 | 0.39 | >12.5 | >12.5 | 0.78 | 0.78 |
Fungi | |||||||||
T. beigelii | 1.56 | 3.13 | 1.56 | 1.56 | 1.56 | 12.5 | 12.5 | 3.13 | 1.56 |
C. albicans | 12.5 | >25 | 25 | 25 | 12.5 | >25 | >25 | >25 | 12.5 |
S. cerevisiae | 12.5 | >25 | 25 | 25 | 25 | >25 | >25 | 25 | 25 |
A. flavus | 25 | 50 | 50 | 50 | 25 | >50 | >50 | 50 | 50 |
A. fumigatus | 12.5 | >50 | 50 | 50 | 25 | >50 | >50 | 50-25 | 50-25 |
F. moniliforme | 12.5 | 25 | 12.5 | 25 | 12.5 | >50 | >50 | 12.5 | 12.5 |
B. cinerea | 1.56 | 12.5 | 6.25 | 6.25 | 3.13 | >50 | >50 | 12.5 | 6.25 |
* melittin
† HP (2-20).