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Cross-linking of ICAM-1 induces selective chemokine secretion from airway epithelial cells. (Figure A. A549 cells) (Figure B. NHBE cells). Cultures were incubated with control IgG1 mAb and anti-mouse IgG F(ab')2 or anti-ICAM-1 mAb and anti-mouse IgG F(ab')2 for the indicated times. Both RANTES and IL-8 was detected in supernatants by ELISA.(n = 6; * = significantly different from control; p < 0.05).
