Figure 6.
Inhibition of ICAM-1 cross-linking induced RANTES secretion from airway epithelial cultures by PD98059 (Figure A. A549 cells) (Figure B. NHBE cells). Epithelial cultures were pre-incubated for 30 minutes in the presence of increasing concentrations of MAP kinase inhibitors. Cultures were then incubated with anti-ICAM-1 mAb and anti-mouse IgG F(ab')2 for 6 hours. Cultures pre-incubated with MAP kinase inhibitors alone had no effect on RANTES secretion. (Results represent means ± SD of triplicate measurements). (n = 6; * = significantly different from control; $ = significantly different from 0.0 μM PD98059; † = significantly different from 0.5 μM PD98059; p < 0.05).