TABLE 3.
In vitro susceptibility of C. albicans parent strain and capping gene deletion mutants to antifungal compounds
| C. albicans strain (relevant phenotype) | MIC (μg/ml)a
|
||||
|---|---|---|---|---|---|
| Amphotericin B | Cycloheximide | Blasticidin S | Hygromycin B | Actinomycin D | |
| BWP17 (parent) | 0.5 | >128 | >32 | 64 | 128 |
| CQF142 (Δcet1/CET1) | 0.5 | >128 | >32 | >128 | 128 |
| CQF152 (Δcet1/Δcet1) | 0.5 | 32 | 32 | 8 | 32 |
| CQF248 (CET1 restored null) | 0.5 | >128 | >32 | >128 | 128 |
| CQF153 (Δcgt1/CGT1) | 0.5 | >128 | >32 | >128 | 128 |
| CQF154 (ΔccmI/CCM1) | 0.5 | >128 | >32 | >128 | 128 |
| CQF171 (Δccm1/ΔccmI) | 0.5 | >128 | >32 | 32 | 64 |
| CQF250 (CCM1 restored null) | 0.5 | >128 | >32 | >128 | 128 |
a
All MIC values were determined after 48 h of incubation, except for strain CQF152, where they were determined after 72 h of incubation due to slow growth even in the no-drug controls.