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. 2002 Dec;1(6):1021–1031. doi: 10.1128/EC.1.6.1021-1031.2002

FIG. 1.

FIG. 1.

Sphingolipid biosynthetic pathway in S. cerevisiae, adapted from Dickson and Lester (19) and Schneiter (37). Genes are shown in capital italic letters. LCB1 encodes a subunit of the serine palmitoyl transferase, FEN1 and SUR4 encode the elongases and are partially redundant, SUR2 encodes a hydroxylase, SUR1 encodes a mannosyl transferase, and IPT1 encodes an inositol phosphotransferase. Abbreviations: CoA, coenzyme A; VLCFA, very long chain fatty acid; PI, phosphatidylinositol; DHS and PHS, sphingoid bases dihydrosphingosine and phytosphingosine, respectively. IPC, inositolphosphorylceramide; MIPC, mannosyl-inositolphosphorylceramide; and M(IP)2C, mannosyl-diinositolphosphorylceramide.